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Barrier-limited, microsecond folding of a stable protein measured with hydrogen exchange: Implications for downhill folding

Folding experiments are conducted to test whether a covalently cross-linked coiled-coil folds so quickly that the process is no longer limited by a free-energy barrier. This protein is very stable and topologically simple, needing merely to “zipper up,” while having an extrapolated folding rate of k...

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Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Meisner, W. Kevin, Sosnick, Tobin R.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2004
Aiheet:
Linkit:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC524831/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15505204/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0404895101
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