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Barrier-limited, microsecond folding of a stable protein measured with hydrogen exchange: Implications for downhill folding
Folding experiments are conducted to test whether a covalently cross-linked coiled-coil folds so quickly that the process is no longer limited by a free-energy barrier. This protein is very stable and topologically simple, needing merely to “zipper up,” while having an extrapolated folding rate of k...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC524831/ https://ncbi.nlm.nih.gov/pubmed/15505204 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404895101 |
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