Fulminant Myocarditis with Combination Immune Checkpoint Blockade

Immune checkpoint inhibitors significantly improve clinical outcomes in numerous malignancies, but high-grade immune-related adverse events can occur, particularly with combination immunotherapy. Herein, we report two melanoma patients who developed fatal myocarditis following treatment with ipilimu...

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Publicado en:N Engl J Med
Autores principales: Johnson, Douglas B., Balko, Justin M., Compton, Margaret L., Chalkias, Spyridon, Gorham, Joshua, Xu, Yaomin, Hicks, Mellissa, Puzanov, Igor, Alexander, Matthew R., Bloomer, Tyler L., Becker, Jason, Slosky, David A., Phillips, Elizabeth J., Pilkinton, Mark A., Craig-Owens, Laura, Kola, Nina, Plautz, Gregory, Reshef, Daniel S., Deutsch, Jonathan S., Deering, Raquel P., Olenchock, Benjamin A., Lichtman, Andrew H., Roden, Dan M., Seidman, Christine E., Koralnik, Igor J., Seidman, Jonathan G., Hoffman, Robert D., Taube, Janis M., Diaz, Luis A., Anders, Robert A., Sosman, Jeffrey A., Moslehi, Javid J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5247797/
https://ncbi.nlm.nih.gov/pubmed/27806233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1609214
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