Molecular Determinants of the Sensitivity to G(q/11)-Phospholipase C-dependent Gating, Gd(3+) Potentiation, and Ca(2+) Permeability in the Transient Receptor Potential Canonical Type 5 (TRPC5) Channel

Transient receptor potential canonical type 5 (TRPC5) is a Ca(2+)-permeable cation channel that is highly expressed in the brain and is implicated in motor coordination, innate fear behavior, and seizure genesis. The channel is activated by a signal downstream of the G-protein-coupled receptor (GPCR...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Chen, Xingjuan, Li, Wennan, Riley, Ashley M., Soliman, Mario, Chakraborty, Saikat, Stamatkin, Christopher W., Obukhov, Alexander G.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2017
Matèries:
Molecular Biophysics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5247662/
https://ncbi.nlm.nih.gov/pubmed/27920205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.755470
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