Carboxyl-terminal Tail-mediated Homodimerizations of Sphingomyelin Synthases Are Responsible for Efficient Export from the Endoplasmic Reticulum

Sphingomyelin synthase (SMS) is the key enzyme for cross-talk between bioactive sphingolipids and glycerolipids. In mammals, SMS consists of two isoforms: SMS1 is localized in the Golgi apparatus, whereas SMS2 is localized in both the Golgi and plasma membranes. SMS2 seems to exert cellular function...

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Udgivet i:J Biol Chem
Main Authors: Hayashi, Yasuhiro, Nemoto-Sasaki, Yoko, Matsumoto, Naoki, Tanikawa, Takashi, Oka, Saori, Tanaka, Yusuke, Arai, Seisuke, Wada, Ikuo, Sugiura, Takayuki, Yamashita, Atsushi
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
Fag:
Lipids
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5247646/
https://ncbi.nlm.nih.gov/pubmed/27927984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.746602
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