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The New Synthetic H(2)S-Releasing SDSS Protects MC3T3-E1 Osteoblasts against H(2)O(2)-Induced Apoptosis by Suppressing Oxidative Stress, Inhibiting MAPKs, and Activating the PI3K/Akt Pathway

Reactive oxygen species (ROS) are important in osteoporosis development. Oxidative stress induces apoptosis of osteoblasts and arrest of their differentiation. Both Danshensu (DSS) and hydrogen sulfide (H(2)S) produce significant antioxidant effect in various systems. In this study, we synthesized S...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Yan, Xiaofei, Wu, Haixia, Wu, Zhiyuan, Hua, Fei, Liang, Dong, Sun, Hong, Yang, Yong, Huang, Dejian, Bian, Jin-Song
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5247634/
https://ncbi.nlm.nih.gov/pubmed/28163684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00007
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