The New Synthetic H(2)S-Releasing SDSS Protects MC3T3-E1 Osteoblasts against H(2)O(2)-Induced Apoptosis by Suppressing Oxidative Stress, Inhibiting MAPKs, and Activating the PI3K/Akt Pathway

Reactive oxygen species (ROS) are important in osteoporosis development. Oxidative stress induces apoptosis of osteoblasts and arrest of their differentiation. Both Danshensu (DSS) and hydrogen sulfide (H(2)S) produce significant antioxidant effect in various systems. In this study, we synthesized S...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Front Pharmacol
Main Authors: Yan, Xiaofei, Wu, Haixia, Wu, Zhiyuan, Hua, Fei, Liang, Dong, Sun, Hong, Yang, Yong, Huang, Dejian, Bian, Jin-Song
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2017
Teme:
Pharmacology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5247634/
https://ncbi.nlm.nih.gov/pubmed/28163684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00007
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