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The New Synthetic H(2)S-Releasing SDSS Protects MC3T3-E1 Osteoblasts against H(2)O(2)-Induced Apoptosis by Suppressing Oxidative Stress, Inhibiting MAPKs, and Activating the PI3K/Akt Pathway
Reactive oxygen species (ROS) are important in osteoporosis development. Oxidative stress induces apoptosis of osteoblasts and arrest of their differentiation. Both Danshensu (DSS) and hydrogen sulfide (H(2)S) produce significant antioxidant effect in various systems. In this study, we synthesized S...
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| Udgivet i: | Front Pharmacol |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Frontiers Media S.A.
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5247634/ https://ncbi.nlm.nih.gov/pubmed/28163684 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00007 |
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