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Kinetically E-Selective Macrocyclic Ring-Closing Metathesis

Macrocyclic compounds are central to discovery of new drugs but their preparation is often challenging because of the energy barrier required for bringing together and fusing the two ends of an acyclic precursor(1). Ring-closing metathesis (RCM) (2,3,4) is a catalytic process that has allowed access...

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Bibliografiske detaljer
Udgivet i:Nature
Main Authors: Shen, Xiao, Nguyen, Thach T., Koh, Ming Joo, Xu, Dongmin, Speed, Alexander W. H., Schrock, Richard R., Hoveyda, Amir H.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5247355/
https://ncbi.nlm.nih.gov/pubmed/28068669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature20800
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