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Orphan receptor ligand discovery by pickpocketing pharmacological neighbors
Understanding the pharmacological similarity of G protein-coupled receptors (GPCRs) is paramount to predicting ligand off-target effects, drug repurposing, and ligand discovery for orphan receptors. Phylogenetic relationships do not always correctly capture pharmacological similarity. Previous famil...
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| Publicado no: | Nat Chem Biol |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5247308/ https://ncbi.nlm.nih.gov/pubmed/27992882 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2266 |
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