Orphan receptor ligand discovery by pickpocketing pharmacological neighbors

Understanding the pharmacological similarity of G protein-coupled receptors (GPCRs) is paramount to predicting ligand off-target effects, drug repurposing, and ligand discovery for orphan receptors. Phylogenetic relationships do not always correctly capture pharmacological similarity. Previous famil...

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Publicat a:Nat Chem Biol
Autors principals: Ngo, Tony, Ilatovskiy, Andrey V., Stewart, Alastair G., Coleman, James L.J., McRobb, Fiona M., Riek, R. Peter, Graham, Robert M., Abagyan, Ruben, Kufareva, Irina, Smith, Nicola J.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5247308/
https://ncbi.nlm.nih.gov/pubmed/27992882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2266
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