Sensitization of melanoma cells to alkylating agent-induced DNA damage and cell death via orchestrating oxidative stress and IKKβ inhibition

Nitrosourea represents one of the most active classes of chemotherapeutic alkylating agents for metastatic melanoma. Treatment with nitrosoureas caused severe systemic side effects which hamper its clinical use. Here, we provide pharmacological evidence that reactive oxygen species (ROS) induction a...

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Veröffentlicht in:Redox Biol
Hauptverfasser: Tse, Anfernee Kai-Wing, Chen, Ying-Jie, Fu, Xiu-Qiong, Su, Tao, Li, Ting, Guo, Hui, Zhu, Pei-Li, Kwan, Hiu-Yee, Cheng, Brian Chi-Yan, Cao, Hui-Hui, Lee, Sally Kin-Wah, Fong, Wang-Fun, Yu, Zhi-Ling
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5247288/
https://ncbi.nlm.nih.gov/pubmed/28107677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.01.010
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