Sensitization of melanoma cells to alkylating agent-induced DNA damage and cell death via orchestrating oxidative stress and IKKβ inhibition

Nitrosourea represents one of the most active classes of chemotherapeutic alkylating agents for metastatic melanoma. Treatment with nitrosoureas caused severe systemic side effects which hamper its clinical use. Here, we provide pharmacological evidence that reactive oxygen species (ROS) induction a...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Tse, Anfernee Kai-Wing, Chen, Ying-Jie, Fu, Xiu-Qiong, Su, Tao, Li, Ting, Guo, Hui, Zhu, Pei-Li, Kwan, Hiu-Yee, Cheng, Brian Chi-Yan, Cao, Hui-Hui, Lee, Sally Kin-Wah, Fong, Wang-Fun, Yu, Zhi-Ling
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5247288/
https://ncbi.nlm.nih.gov/pubmed/28107677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.01.010
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