The soluble cytoplasmic tail of CD45 (ct‐CD45) in human plasma contributes to keep T cells in a quiescent state

The cytoplasmic tail of CD45 (ct‐CD45) is proteolytically cleaved and released upon activation of human phagocytes. It acts on T cells as an inhibitory, cytokine‐like factor in vitro. Here, we show that ct‐CD45 is abundant in human peripheral blood plasma from healthy adults compared with plasma der...

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Detalhes bibliográficos
Publicado no:Eur J Immunol
Main Authors: Puck, Alexander, Hopf, Stefan, Modak, Madhura, Majdic, Otto, Cejka, Petra, Blüml, Stephan, Schmetterer, Klaus, Arnold‐Schrauf, Catharina, Gerwien, Jens G., Frederiksen, Klaus S., Thell, Elisabeth, Leitner, Judith, Steinberger, Peter, Aigner, Regina, Seyerl‐Jiresch, Maria, Zlabinger, Gerhard J., Stöckl, Johannes
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Immunomodulation and immune therapies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5244668/
https://ncbi.nlm.nih.gov/pubmed/27718235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201646405
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