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Methyl-Cytosine-Driven Structural Changes Enhance Adduction Kinetics of an Exon 7 fragment of the p53 Gene

Methylation of cytosine (C) at C-phosphate-guanine (CpG) sites enhances reactivity of DNA towards electrophiles. Mutations at CpG sites on the p53 tumor suppressor gene that can result from these adductions are in turn correlated with specific cancers. Here we describe the first restriction-enzyme-a...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Malla, Spundana, Kadimisetty, Karteek, Fu, You-Jun, Choudhary, Dharamainder, Schenkman, John B., Rusling, James F.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5244379/
https://ncbi.nlm.nih.gov/pubmed/28102315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep40890
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