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Chemical selectivity of nucleobase adduction relative to in vivo mutation sites on exon 7 fragment of p53 tumor suppressor gene

Damage to p53 tumor suppressor gene is found in half of all human cancers. Databases integrating studies of large numbers of tumors and cancer cell cultures show that mutation sites of specific p53 codons are correlated with specific types of cancers. If the most frequently damaged p53 codons in viv...

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Bibliografske podrobnosti
izdano v:Chem Sci
Main Authors: Malla, Spundana, Kadimisetty, Karteek, Fu, You-Jun, Choudhary, Dharamainder, Jansson, Ingela, Schenkman, John B., Rusling, James F.
Format: Artigo
Jezik:Inglês
Izdano: Royal Society of Chemistry 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583204/
https://ncbi.nlm.nih.gov/pubmed/26417421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc01403d
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