Adeno-associated Virus (AAV) Assembly-Activating Protein Is Not an Essential Requirement for Capsid Assembly of AAV Serotypes 4, 5, and 11

Adeno-associated virus (AAV) vectors have made great progress in their use for gene therapy; however, fundamental aspects of AAV's capsid assembly remain poorly characterized. In this regard, the discovery of assembly-activating protein (AAP) sheds new light on this crucial part of AAV biology...

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Vydáno v:J Virol
Hlavní autoři: Earley, Lauriel F., Powers, John M., Adachi, Kei, Baumgart, Joshua T., Meyer, Nancy L., Xie, Qing, Chapman, Michael S., Nakai, Hiroyuki
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
Témata:
Gene Delivery
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5244341/
https://ncbi.nlm.nih.gov/pubmed/27852862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01980-16
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