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Cryo-electron Microscopy Structures of Expanded Poliovirus with VHHs Sample the Conformational Repertoire of the Expanded State

By using cryo-electron microscopy, expanded 80S-like poliovirus virions (poliovirions) were visualized in complexes with four 80S-specific camelid VHHs (Nanobodies). In all four complexes, the VHHs bind to a site on the top surface of the capsid protein VP3, which is hidden in the native virus. Inte...

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書目詳細資料
發表在:J Virol
Main Authors: Strauss, Mike, Schotte, Lise, Karunatilaka, Krishanthi S., Filman, David J., Hogle, James M.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5244317/
https://ncbi.nlm.nih.gov/pubmed/27852863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01443-16
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