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The integrin α-subunit leg extends at a Ca(2+)-dependent epitope in the thigh/genu interface upon activation
Two activation-dependent Abs to the integrin α(L)-subunit were used to study conformational rearrangement of α(L)β(2) on the cell surface. Activation lowered the concentration of Ca(2+) required for maximal expression of each epitope. Each Ab requires the Ca(2+)-binding loop in the integrin genu and...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2004
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC524430/ https://ncbi.nlm.nih.gov/pubmed/15494438 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406680101 |
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