Sequential C–H Arylation and Enantioselective Hydrogenation Enables Ideal Asymmetric Entry to the Indenopiperidine Core of an 11β-HSD-1 Inhibitor

A concise asymmetric synthesis of an 11β-HSD-1 inhibitor has been achieved using inexpensive starting materials with excellent step-economy at low catalyst loadings. The catalytic enantioselective total synthesis of 1 was accomplished in 7 steps and 38% overall yield aided by the development of an i...

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Publicado no:J Am Chem Soc
Main Authors: Wei, Xudong, Qu, Bo, Zeng, Xingzhong, Savoie, Jolaine, Fandrick, Keith R., Desrosiers, Jean-Nicolas, Tcyrulnikov, Sergei, Marsini, Maurice A., Buono, Frederic G., Li, Zhibin, Yang, Bing-Shiou, Tang, Wenjun, Haddad, Nizar, Gutierrez, Osvaldo, Wang, Jun, Lee, Heewon, Ma, Shengli, Campbell, Scot, Lorenz, Jon C., Eckhardt, Matthias, Himmelsbach, Frank, Peters, Stefan, Patel, Nitinchandra D., Tan, Zhulin, Yee, Nathan K., Song, Jinhua J., Roschangar, Frank, Kozlowski, Marisa C., Senanayake, Chris H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5243942/
https://ncbi.nlm.nih.gov/pubmed/27794616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b09764
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