Computationally Assisted Mechanistic Investigation and Development of Pd-Catalyzed Asymmetric Suzuki-Miyaura and Negishi Cross-Coupling Reactions for Tetra-ortho-Substituted Biaryl Synthesis

Metal-catalyzed cross-coupling reactions are extensively employed in both academia and industry for the synthesis of biaryl derivatives for applications to both medicine and material science. Application of these methods to prepare tetra-ortho-substituted biaryls leads to chiral atropisomeric produc...

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Publicado no:ACS Catal
Main Authors: Patel, Nitinchandra Dahyabhai, Sieber, Joshua D., Tcyrulnikov, Sergei, Simmons, Bryan J., Rivalti, Daniel, Duvvuri, Krishnaja, Zhang, Yongda, Gao, Donghong A., Fandrick, Keith R., Haddad, Nizar, Lao, Kendricks So, Mangunuru, Hari Prasad Reddy, Biswas, Soumik, Qu, Bo, Grinberg, Nelu, Pennino, Scott, Lee, Heewon, Song, Jinhua J., Gupton, B. Frank, Garg, Neil K., Kozlowski, Marisa C., Senanayake, Chris H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6234982/
https://ncbi.nlm.nih.gov/pubmed/30450265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.8b02509
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