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Mutant actins that stabilise F-actin use distinct mechanisms to activate the SRF coactivator MAL

Nuclear accumulation of the serum response factor coactivator MAL/MKL1 is controlled by its interaction with G-actin, which results in its retention in the cytoplasm in cells with low Rho activity. We previously identified actin mutants whose expression promotes MAL nuclear accumulation via an unkno...

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Udgivet i:EMBO J
Principais autores: Posern, Guido, Miralles, Francesc, Guettler, Sebastian, Treisman, Richard
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2004
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC524340/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15385960/
https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600404
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