Mutant actins that stabilise F-actin use distinct mechanisms to activate the SRF coactivator MAL

Nuclear accumulation of the serum response factor coactivator MAL/MKL1 is controlled by its interaction with G-actin, which results in its retention in the cytoplasm in cells with low Rho activity. We previously identified actin mutants whose expression promotes MAL nuclear accumulation via an unkno...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Posern, Guido, Miralles, Francesc, Guettler, Sebastian, Treisman, Richard
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2004
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC524340/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15385960/ https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600404
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