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Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members

The Alzheimer's disease β-amyloid precursor protein (APP) is a member of a larger gene family that includes the amyloid precursor-like proteins, termed APLP1 and APLP2. We previously documented that APLP2(−/−)APLP1(−/−) and APLP2(−/−)APP(−/−) mice die postnatally, while APLP1(−/−)APP(−/−) mice...

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Detalhes bibliográficos
Main Authors: Herms, Jochen, Anliker, Brigitte, Heber, Sabine, Ring, Sabine, Fuhrmann, Martin, Kretzschmar, Hans, Sisodia, Sangram, Müller, Ulrike
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2004
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC524337/
https://ncbi.nlm.nih.gov/pubmed/15385965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600390
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