Mice with Combined Gene Knock-Outs Reveal Essential and Partially Redundant Functions of Amyloid Precursor Protein Family Members

The amyloid precursor protein (APP) involved in Alzheimer's disease is a member of a larger gene family including amyloid precursor-like proteins APLP1 and APLP2. We generated and examined the phenotypes of mice lacking individual or all possible combinations of APP family members to assess pot...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Heber, Sabine, Herms, Jochen, Gajic, Vladan, Hainfellner, Johannes, Aguzzi, Adriano, Rülicke, Thomas, Kretzschmar, Hans, von Koch, Cornelia, Sisodia, Sangram, Tremml, Phillippe, Lipp, Hans-Peter, Wolfer, David P., Müller, Ulrike
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2000
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772747/
https://ncbi.nlm.nih.gov/pubmed/11050115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-21-07951.2000
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