Variation of free‐energy landscape of the p53 C‐terminal domain induced by acetylation: Enhanced conformational sampling

The C‐terminal domain (CTD) of tumor suppressor protein p53 is an intrinsically disordered region that binds to various partner proteins, where lysine of CTD is acetylated/nonacetylated and histidine neutralized/non‐neutralized. Because of the flexibility of the unbound CTD, a free‐energy landscape...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:J Comput Chem
Main Authors: Iida, Shinji, Mashimo, Tadaaki, Kurosawa, Takashi, Hojo, Hironobu, Muta, Hiroya, Goto, Yuji, Fukunishi, Yoshifumi, Nakamura, Haruki, Higo, Junichi
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2016
Assuntos:
Full Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5242334/
https://ncbi.nlm.nih.gov/pubmed/27735058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcc.24494
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares