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Reliable and efficient solution of genome-scale models of Metabolism and macromolecular Expression

Constraint-Based Reconstruction and Analysis (COBRA) is currently the only methodology that permits integrated modeling of Metabolism and macromolecular Expression (ME) at genome-scale. Linear optimization computes steady-state flux solutions to ME models, but flux values are spread over many orders...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Ma, Ding, Yang, Laurence, Fleming, Ronan M. T., Thiele, Ines, Palsson, Bernhard O., Saunders, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5241643/
https://ncbi.nlm.nih.gov/pubmed/28098205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep40863
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