Method Development and Validation for the Quantitation of the Complement Inhibitor Cp40 in Human and Cynomolgus Monkey Plasma by UPLC-ESI-MS

Cp40 is a 14-amino acid cyclic analog of the peptidic complement inhibitor compstatin that binds with sub-nanomolar affinity to complement component C3 and has already shown promise in various models of complement-related diseases. The preclinical and clinical development of this compound requires a...

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Bibliographic Details
Published in:J Chromatogr B Analyt Technol Biomed Life Sci
Main Authors: Primikyri, Alexandra, Papanastasiou, Malvina, Sarigiannis, Yiannis, Koutsogiannaki, Sophia, Reis, Edimara S., Tuplano, Joel V., Resuello, Ranillo R. G., Nilsson, Bo, Ricklin, Daniel, Lambris, John D.
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5241290/
https://ncbi.nlm.nih.gov/pubmed/27992787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2016.12.004
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