Inhibition of pre-existing natural periodontitis in non-human primates by a locally administered peptide inhibitor of complement C3

AIM: Human periodontitis is associated with overactivation of complement, which is triggered by different mechanisms converging on C3, the central hub of the system. We assessed whether the C3 inhibitor Cp40 inhibits naturally-occurring periodontitis in non-human primates. MATERIALS AND METHODS: Non...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Clin Periodontol
Prif Awduron: Maekawa, Tomoki, Briones, Ruel A., Resuello, Ranillo R.G., Tuplano, Joel V., Hajishengallis, Evlambia, Kajikawa, Tetsuhiro, Koutsogiannaki, Sophia, Garcia, Cristina A.G., Ricklin, Daniel, Lambris, John D., Hajishengallis, George
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4803614/
https://ncbi.nlm.nih.gov/pubmed/26728318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcpe.12507
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