Deletion of Nlrp3 protects from inflammation-induced skeletal muscle atrophy

BACKGROUND: Critically ill patients develop atrophic muscle failure, which increases morbidity and mortality. Interleukin-1β (IL-1β) is activated early in sepsis. Whether IL-1β acts directly on muscle cells and whether its inhibition prevents atrophy is unknown. We aimed to investigate if IL-1β acti...

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Vydáno v:Intensive Care Med Exp
Hlavní autoři: Huang, Nora, Kny, Melanie, Riediger, Fabian, Busch, Katharina, Schmidt, Sibylle, Luft, Friedrich C., Slevogt, Hortense, Fielitz, Jens
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2017
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5241267/
https://ncbi.nlm.nih.gov/pubmed/28097512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40635-016-0115-0
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