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Non-Homologous End Joining and Homology Directed DNA Repair Frequency of Double-Stranded Breaks Introduced by Genome Editing Reagents

Genome editing using transcription-activator like effector nucleases or RNA guided nucleases allows one to precisely engineer desired changes within a given target sequence. The genome editing reagents introduce double stranded breaks (DSBs) at the target site which can then undergo DNA repair by no...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Zaboikin, Michail, Zaboikina, Tatiana, Freter, Carl, Srinivasakumar, Narasimhachar
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5241150/
https://ncbi.nlm.nih.gov/pubmed/28095454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0169931
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