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Gaussian decomposition of high-resolution melt curve derivatives for measuring genome-editing efficiency

We describe a method for measuring genome editing efficiency from in silico analysis of high-resolution melt curve data. The melt curve data derived from amplicons of genome-edited or unmodified target sites were processed to remove the background fluorescent signal emanating from free fluorophore a...

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Pubblicato in:PLoS One
Autori principali: Zaboikin, Michail, Freter, Carl, Srinivasakumar, Narasimhachar
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5754072/
https://ncbi.nlm.nih.gov/pubmed/29300734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0190192
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