Anti-Prion Screening for Acridine, Dextran, and Tannic Acid using Real Time–Quaking Induced Conversion: A Comparison with PrP(Sc)-Infected Cell Screening

Prion propagation is mediated by the structural alteration of normal prion protein (PrP(C)) to generate pathogenic prion protein (PrP(Sc)). To date, compounds for the inhibition of prion propagation have mainly been screened using PrP(Sc)-infected cells. Real time–quaking-induced conversion (RT-QuIC...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Hyeon, Jae Wook, Kim, Su Yeon, Lee, Sol Moe, Lee, Jeongmin, An, Seong Soo A., Lee, Myung Koo, Lee, Yeong Seon
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5240994/
https://ncbi.nlm.nih.gov/pubmed/28095474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0170266
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