The Smc5/6 Complex Restricts HBV when Localized to ND10 without Inducing an Innate Immune Response and Is Counteracted by the HBV X Protein Shortly after Infection

The structural maintenance of chromosome 5/6 complex (Smc5/6) is a restriction factor that represses hepatitis B virus (HBV) transcription. HBV counters this restriction by expressing HBV X protein (HBx), which targets Smc5/6 for degradation. However, the mechanism by which Smc5/6 suppresses HBV tra...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Niu, Congrong, Livingston, Christine M., Li, Li, Beran, Rudolf K., Daffis, Stephane, Ramakrishnan, Dhivya, Burdette, Dara, Peiser, Leanne, Salas, Eduardo, Ramos, Hilario, Yu, Mei, Cheng, Guofeng, Strubin, Michel, Delaney IV, William E., Fletcher, Simon P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5240991/
https://ncbi.nlm.nih.gov/pubmed/28095508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0169648
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