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Hepatitis B Virus X protein promotes degradation of SMC5/6 to enhance HBV replication
The Hepatitis B Virus (HBV) regulatory protein X (HBx) activates gene expression from the HBV covalently closed circular (cccDNA) genome. Interaction of HBx with the DDB1-CUL4-ROC1 (CRL4) E3 ligase is critical for this function. Using substrate-trapping proteomics, we identified the structural maint...
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| Publicado no: | Cell Rep |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5078993/ https://ncbi.nlm.nih.gov/pubmed/27626656 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.08.026 |
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