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Toll-like Receptor 4 Mediates Morphine-Induced Neuroinflammation and Tolerance via Soluble Tumor Necrosis Factor Signaling

Opioid tolerance and the potential for addiction is a significant burden associated with pain management, yet its precise underlying mechanism and prevention remain elusive. Immune signaling contributes to the decreased efficacy of opioids, and we recently demonstrated that Toll-like receptor 4 (TLR...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Neuropsychopharmacology
Hauptverfasser: Eidson, Lori N, Inoue, Kiyoshi, Young, Larry J, Tansey, Malu G, Murphy, Anne Z
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5240168/
https://ncbi.nlm.nih.gov/pubmed/27461080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2016.131
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