Hexavalent chromium induces malignant transformation of human lung bronchial epithelial cells via ROS-dependent activation of miR-21-PDCD4 signaling

Hexavalent chromium [Cr(VI)] is a well-known human carcinogen associated with an increased risk of lung cancer. However, the mechanisms underlying Cr(VI)-induced carcinogenesis remain unclear. MicroRNA-21 (miR-21) is a key regulator of oncogenic processes. Studies have shown that miR-21 exerts its o...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Pratheeshkumar, Poyil, Son, Young-Ok, Divya, Sasidharan Padmaja, Turcios, Lilia, Roy, Ram Vinod, Hitron, John Andrew, Wang, Lei, Kim, Donghern, Dai, Jin, Asha, Padmaja, Zhang, Zhuo, Shi, Xianglin
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5239469/
https://ncbi.nlm.nih.gov/pubmed/27323401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9967
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