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Oncogenic transformation of human lung bronchial epithelial cells induced by arsenic involves ROS-dependent activation of STAT3-miR-21-PDCD4 mechanism

Arsenic is a well-documented human carcinogen. The present study explored the role of the onco-miR, miR-21 and its target protein, programmed cell death 4 (PDCD4) in arsenic induced malignant cell transformation and tumorigenesis. Our results showed that treatment of human bronchial epithelial (BEAS...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Pratheeshkumar, Poyil, Son, Young-Ok, Divya, Sasidharan Padmaja, Wang, Lei, Zhang, Zhuo, Shi, Xianglin
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5120334/
https://ncbi.nlm.nih.gov/pubmed/27876813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep37227
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