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Using induced pluripotent stems cells to understand retinal ciliopathy disease mechanisms and develop therapies

The photoreceptor cells in the retina have a highly specialized sensory cilium, the outer segment, which is important for detecting light. Mutations in cilia related genes often result in retinal degeneration. The ability to reprogram human cells into induced pluripotent stem cells (iPSCs) and then...

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Podrobná bibliografie
Vydáno v:Biochem Soc Trans
Hlavní autoři: Parfitt, David A., Lane, Amelia, Ramsden, Conor, Jovanovic, Katarina, Coffey, Peter J., Hardcastle, Alison J., Cheetham, Michael E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5238943/
https://ncbi.nlm.nih.gov/pubmed/27911706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20160156
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