Functional genomics reveals that tumors with activating phosphoinositide 3-kinase mutations are dependent on accelerated protein turnover

Activating mutations in the phosphoinositide 3-kinase (PI3K) signaling pathway are frequently identified in cancer. To identify pathways that support PI3K oncogenesis, we performed a genome-wide RNAi screen in isogenic cell lines harboring wild-type or mutant PIK3CA to search for PI3K synthetic-leth...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Davoli, Teresa, Mengwasser, Kristen E., Duan, Jingjing, Chen, Ting, Christensen, Camilla, Wooten, Eric C., Anselmo, Anthony N., Li, Mamie Z., Wong, Kwok-Kin, Kahle, Kristopher T., Elledge, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5238728/
https://ncbi.nlm.nih.gov/pubmed/28087713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.290122.116
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