Icaritin enhances mESC self-renewal through upregulating core pluripotency transcription factors mediated by ERα

Utilization of small molecules in modulation of stem cell self-renewal is a promising approach to expand stem cells for regenerative therapy. Here, we identify Icaritin, a phytoestrogen molecule enhances self-renewal of mouse embryonic stem cells (mESCs). Icaritin increases mESCs proliferation while...

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Publicat a:Sci Rep
Autors principals: Tsang, Wing Pui, Zhang, Fengjie, He, Qiling, Cai, Waijiao, Huang, Jianhua, Chan, Wai Yee, Shen, Ziyin, Wan, Chao
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5238509/
https://ncbi.nlm.nih.gov/pubmed/28091581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep40894
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