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Noncanonical function of DGCR8 controls mESC exit from pluripotency
Mouse embryonic stem cells (mESCs) deficient for DGCR8, a key component of the microprocessor complex, present strong differentiation defects. However, the exact reasons impairing their commitment remain elusive. The analysis of newly generated mutant mESCs revealed that DGCR8 is essential for the e...
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| Published in: | J Cell Biol |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
The Rockefeller University Press
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5294780/ https://ncbi.nlm.nih.gov/pubmed/28100686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201606073 |
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