Noncanonical function of DGCR8 controls mESC exit from pluripotency

Mouse embryonic stem cells (mESCs) deficient for DGCR8, a key component of the microprocessor complex, present strong differentiation defects. However, the exact reasons impairing their commitment remain elusive. The analysis of newly generated mutant mESCs revealed that DGCR8 is essential for the e...

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Bibliographic Details
Published in:J Cell Biol
Main Authors: Cirera-Salinas, Daniel, Yu, Jian, Bodak, Maxime, Ngondo, Richard P., Herbert, Kristina M., Ciaudo, Constance
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2017
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5294780/
https://ncbi.nlm.nih.gov/pubmed/28100686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201606073
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