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Noncanonical function of DGCR8 controls mESC exit from pluripotency

Mouse embryonic stem cells (mESCs) deficient for DGCR8, a key component of the microprocessor complex, present strong differentiation defects. However, the exact reasons impairing their commitment remain elusive. The analysis of newly generated mutant mESCs revealed that DGCR8 is essential for the e...

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Dades bibliogràfiques
Publicat a:J Cell Biol
Autors principals: Cirera-Salinas, Daniel, Yu, Jian, Bodak, Maxime, Ngondo, Richard P., Herbert, Kristina M., Ciaudo, Constance
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5294780/
https://ncbi.nlm.nih.gov/pubmed/28100686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201606073
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