Bivalent IAP antagonists, but not monovalent IAP antagonists, inhibit TNF-mediated NF-κB signaling by degrading TRAF2-associated cIAP1 in cancer cells

The inhibitor of apoptosis (IAP) proteins have pivotal roles in cell proliferation and differentiation, and antagonizing IAPs in certain cancer cell lines results in induction of cell death. A variety of IAP antagonist compounds targeting the baculovirus IAP protein repeat 3 (BIR3) domain of cIAP1ha...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Cell Death Discov
Main Authors: Mitsuuchi, Y, Benetatos, CA, Deng, Y, Haimowitz, T, Beck, SC, Arnone, MR, Kapoor, GS, Seipel, ME, Chunduru, SK, McKinlay, MA, Begley, CG, Condon, SM
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5238498/
https://ncbi.nlm.nih.gov/pubmed/28149532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddiscovery.2016.46
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki