The Hypothesis of the Human iNKT/Innate CD8(+) T-Cell Axis Applied to Cancer: Evidence for a Deficiency in Chronic Myeloid Leukemia

We recently identified a new human subset of NK-like [KIR/NKG2A(+)] CD8(+) T cells with a marked/memory phenotype, high Eomesodermin expression, potent antigen-independent cytotoxic activity, and the capacity to generate IFN-γ rapidly after exposure to pro-inflammatory cytokines. These features supp...

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Vydáno v:Front Immunol
Hlavní autoři: Jacomet, Florence, Cayssials, Emilie, Barbarin, Alice, Desmier, Deborah, Basbous, Sara, Lefèvre, Lucie, Levescot, Anaïs, Robin, Aurélie, Piccirilli, Nathalie, Giraud, Christine, Guilhot, François, Roy, Lydia, Herbelin, André, Gombert, Jean-Marc
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2017
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5237805/
https://ncbi.nlm.nih.gov/pubmed/28138330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00688
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