A multifunctional expression vector for an anti-HIV-1 ribozyme that produces a 5'- and 3'-trimmed trans-acting ribozyme, targeted against HIV-1 RNA, and cis-acting ribozymes that are designed to bind to and thereby sequester trans-activator proteins such as Tat and Rev.

Ítems similars

• Importance of independence in ribozyme reactions: kinetic behavior of trimmed and of simply connected multiple ribozymes with potential activity against human immunodeficiency virus.
  per: Ohkawa, J, et al.
  Publicat: (1993)
• Inhibition of HIV-1 expression and replication by SOFA-HDV ribozymes against Tat and Rev mRNA sequences
  per: Lainé, Sébastien, et al.
  Publicat: (2009)
• The human I-mfa domain containing protein, HIC, interacts with HIV-1 Tat and Rev and sequesters them in the cytoplasm
  per: Gu, L, et al.
  Publicat: (2006)
• HIV-1 tat and rev upregulates osteoclast bone resorption
  per: Chew, Nicholas, et al.
  Publicat: (2014)
• A circular trans-acting hepatitis delta virus ribozyme.
  per: Puttaraju, M, et al.
  Publicat: (1993)