Thorough QT study of the effect of intravenous amisulpride on QTc interval in Caucasian and Japanese healthy subjects

AIM: The D(2)/D(3) antagonist amisulpride has shown promising efficacy against postoperative nausea and vomiting (PONV) at low doses. We investigated whether intravenous amisulpride has an effect on the QTc interval in a formal Thorough QT study (TQT). METHODS: This was a randomized, double‐blind, p...

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Vydáno v:Br J Clin Pharmacol
Hlavní autoři: Täubel, Jörg, Ferber, Georg, Fox, Gabriel, Fernandes, Sara, Lorch, Ulrike, Camm, A. John
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
Témata:
Clinical Trials
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5237697/
https://ncbi.nlm.nih.gov/pubmed/27618796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13128
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