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An S‐warfarin and AZD1981 interaction: in vitro and clinical pilot data suggest the N‐deacetylated amino acid metabolite as the primary perpetrator

AIM: AZD1981 is an orally bioavailable chemoattractant receptor‐homologous molecule expressed on Th2 cells (CRTh2) receptor antagonist progressed to phase II trials for the treatment of allergic asthma. Previously performed in vitro human hepatocyte incubations identified N‐deacetylated AZD1981 as a...

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Bibliografski detalji
Izdano u:Br J Clin Pharmacol
Glavni autori: Grime, Ken, Pehrson, Rikard, Nordell, Pär, Gillen, Michael, Kühn, Wolfgang, Mant, Timothy, Brännström, Marie, Svanberg, Petter, Jones, Barry, Brealey, Clive
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5237683/
https://ncbi.nlm.nih.gov/pubmed/27558866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13102
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