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Characterization of Runella slithyformis HD-Pnk, a Bifunctional DNA/RNA End-Healing Enzyme Composed of an N-Terminal 2′,3′-Phosphoesterase HD Domain and a C-Terminal 5′-OH Polynucleotide Kinase Domain
5′- and 3′-end-healing reactions are key steps in nucleic acid break repair in which 5′-OH ends are phosphorylated by a polynucleotide kinase (Pnk) and 3′-PO(4) or 2′,3′-cyclic-PO(4) ends are hydrolyzed by a phosphoesterase to generate the 5′-PO(4) and 3′-OH termini required for sealing by classic p...
Guardat en:
| Publicat a: | J Bacteriol |
|---|---|
| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5237116/ https://ncbi.nlm.nih.gov/pubmed/27895092 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00739-16 |
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