Mutational analysis of the DNA binding domain A of chromosomal protein HMG1.
We have mutated several residues of the first of the two HMG-boxes of mammalian HMG1. Some mutants cannot be produced in Escherichia coli, suggesting that the peptide fold is grossly disrupted. A few others can be produced efficiently and have normal DNA binding affinity and specificity; however, th...
Uloženo v:
| Vydáno v: | Nucleic Acids Res |
|---|---|
| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Oxford University Press
1994
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| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC523578/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8127664/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/22.3.285 |
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