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Mutational analysis of the DNA binding domain A of chromosomal protein HMG1.
We have mutated several residues of the first of the two HMG-boxes of mammalian HMG1. Some mutants cannot be produced in Escherichia coli, suggesting that the peptide fold is grossly disrupted. A few others can be produced efficiently and have normal DNA binding affinity and specificity; however, th...
Uloženo v:
| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
1994
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC523578/ https://ncbi.nlm.nih.gov/pubmed/8127664 |
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