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Targeted disruption of the orphan receptor Gpr151 does not alter pain-related behaviour despite a strong induction in dorsal root ganglion expression in a model of neuropathic pain

BACKGROUND: Gpr151 is an orphan GPCR whose function is unknown. The restricted pattern of neuronal expression in the habenula, dorsal horn of the spinal cord and dorsal root ganglion plus homology with the galanin family of receptors imply a role in nociception. RESULTS: Real-time quantitative RT-PC...

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Publicat a:Mol Cell Neurosci
Autors principals: Holmes, Fiona E., Kerr, Niall, Chen, Ying-Ju, Vanderplank, Penny, McArdle, Craig A., Wynick, David
Format: Artigo
Idioma:Inglês
Publicat: Academic Press 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5235321/
https://ncbi.nlm.nih.gov/pubmed/27913310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2016.11.010
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