A semi-synthetic oligosaccharide conjugate vaccine candidate confers protection against Streptococcus pneumoniae serotype 3 infection

The identification of immunogenic glycotopes that render glycoconjugate vaccines protective is key to improving vaccine efficacy. Synthetic oligosaccharides are an attractive alternative to the heterogeneous preparations of purified polysaccharides that most marketed glycoconjugate vaccines are base...

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Publicado en:Cell Chem Biol
Autores principales: Parameswarappa, Sharavathi Guddehalli, Reppe, Katrin, Geissner, Andreas, Ménová, Petra, Govindan, Subramanian, Calow, Adam D. J., Wahlbrink, Annette, Weishaupt, Markus W., Monnanda, Bopanna Ponnappa, Bell, Roland Lawrence, Pirofski, Liise-anne, Suttorp, Norbert, Sander, Leif Erik, Witzenrath, Martin, Pereira, Claney Lebev, Anish, Chakkumkal, Seeberger, Peter H.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5234679/
https://ncbi.nlm.nih.gov/pubmed/27818299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.09.016
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